ECM-derived Tetrapeptide to Counterbalance ECM Degeneration

The extracellular matrix (ECM) is the structural backbone of many tissues, especially the skin, and represents a main target for cosmetic applications. ECM proteins are believed to play a pivotal role in cellular migration, proliferation and gene regulation during wound healing. Fragments from ECM constituents have been found capable of stimulating ECM biosynthesis to compensate for tissue destruction.1 Their mechanisms have been implicated in wound healing, skin aging and skin’s response to UV irradiation;2, 3 from this knowledge, new actives have evolved, as the authors describe here.

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