Poly glutamic acid: A Novel Peptide for Skin Care

By: Natalie Ben-Zur, Natto Biosciences, Daniel M. Goldman, Supreme Business Services Inc.

Posted: April 2, 2007, from the April 2007 issue of Cosmetics & Toiletries.

γ-Poly glutamic acid (γ-PGA) is a novel molecule that is a component of the mucilage of the fermented soybean food product commonly found in Japan called natto. The International Nomenclature Cosmetic Ingredient (INCI) name of γ-PGA is natto gum and it is classified as a film-forming agent. The sodium salt of γ-PGA, which is more commonly used and thus served as the test sample in this paper, displays the visual appearance of a sticky paste as illustrated in Figure 1. 

The fermented soybean mucilage consists of a mixture of γ-PGA and fructan produced by Bacillus natto. Further research by Bovarnick revealed γ-PGA to be a fermentation byproduct freely secreted into growth medium outside of the cell walls of Bacillus subtilis. This discovery advanced collateral investigations to determine whether this bacteriological process could be reproduced in other species of Bacillus.

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