Recent in Delivery (page 6 of 6)

Delivering Actives via Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Part I

This first of a two-part series on SLNs and NLCs describes the differences between the two types and their delivery capabilities. The terms solid lipid nanoparticles and nanostructured lipid carriers are not very useful to distinguish these two delivery systems since both are solid, both are lipids, both are nanoparticles, and both are carrier systems. The only real difference between the two is the purity of the single lipid used in SLNs or multiple lipids used, i.e. one solid and one liquid, in NLCs. This factor has an enormous impact on the crystallinity of the lipid phase, which subsequently influences the loading capacity of the system for encapsulated active ingredients or API.

Environmentally Responsive Nanoparticles for Delivery as Assessed via Light Scattering and Near-infrared Imaging

Lipid-based nanoparticles were developed to respond to environmental stimuli and used as site-directed delivery systems. Through Dynamic Light Scattering (DLS), the self-assembly of these 10–40 nm particles was observed. In addition, the penetration of the particles through the stratum corneum was monitored in vivo using a novel Near-infrared Chemical Imaging (NIR-CI) technique.

Controlled-release Mechanisms of Fragrances

Fragrances are volatile and susceptible to oxidation, and can escape from a finished product over time. This limited longevity has led to the development of encapsulation and controlled-release techniques. The present article reviews methods for controlling the release of fragrance in personal care products, and describes their mechanisms of action.

Study Finds Growth in Beauty-related Nanotechnology Patents

The number of nanotechnology patents related to personal care products has grown 103% in the past seven years, according to an analysis of world patent activity published by the IP Solutions business of Thomson Reuters.

Dendrimersomes for Ingredient Delivery

According to Virgil Percec, PhD, a professor at the University of Pennsylvania, dendrimers are the answer to the stable, effective delivery of drugs and cosmetic actives to the skin. Percec’s team has researched the fundamentals of dendrimers for years but more recently published work on using dendrimers to deliver drugs, cosmetic ingredients and other materials to the skin.

Researchers Develop 'Dendrimersomes' for Cosmetic Delivery

Researchers from several establishments under the leadership of the University of Pennsylvania have developed nano-assemblies of Janus dendrimers, termed dendrimersomes, for the delivery of cosmetics, drugs, proteins and more.

Waterless Foam Patented for Active Delivery

Foamix Ltd. has received a patent (US Pat. 7,704,518) for its Hygroscopic and Waterless Breakable Foam. This patent, titled "Foamable vehicle and pharmaceutical compositions thereof," describes a pharmaceutical foam that is able to deliver a wide range of active agents to treat skin and body cavity conditions.

Spherical Beads for Active, Pigment, Fragrance Delivery

At In-Cosmetics in Paris, Induchem introduced spherical beads based on cellulose, sugars and pigments. Unispheres can be loaded with lipophilic actives, fragrances, glitter, shimmer or pigments.

It's a Small World

This issue of Cosmetics & Toiletries magazine also looks within the nano-sized world to examine the benefits that tiny technologies can impart in personal care. Delivery is one benefit. While debate surrounds the depth to which they penetrate skin, nanomaterials are nonetheless believed by most experts to do so, to some degree.

Chitin Nanofibrils for Cosmetic Delivery

In the present article, the author explores the delivery capabilities of nanocrystal chitin nanofibrils. By establishing an ionic bond with water and forming complexes with various actives, this material can impart local or global activity and reach different levels of skin permeability to achieve variable cosmetic efficacy.

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