Recent in Delivery (page 5 of 6)

Compass—Ties That Bind

Binding is not a new phenomenon, but interest in it continues for improved ingredient delivery and efficacy.

Saccharide Isomerate to Deeply Hydrate Skin and Scalp

Saccharide isomerate, designed to closely resemble a carbohydrate complex found in human stratum corneum, is shown here to provide up to 72 hr of deep hydration to skin and, for the first time, rinse-off soothing to the scalp. Its unique binding mechanism to skin and scalp create new opportunities for leave-on and rinse-off products.

Formulating Focus—Delivering Actives via Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Part IV, Percutaneous Absorption and Dermal Cosmetic Formulations

In this fourth part of a five-part series discusses the percutaneous absorption of actives loaded into solid lipid SLNs and NLCs and their formulation in dermal cosmetics.

Pseudopeptidic Compounds for Biocompatible Gels: A Review

Simple pseudopeptides derived from natural amino acids can be designed and prepared as efficient gelators for a variety of solvents, and with a high potential for biocompatibility. The appropriate selection of structural components, reviewed herein, shows how to produce gels with tailored properties, including high thermal stability.

Formulating Focus—Delivering Actives via Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Part III, Stability and Efficacy

Part I of this review on Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs) discussed the differences of these two delivery systems for cosmetic actives, as well as their production methods and selection criteria for constituents. In Part II, the characterization of these nano-sized particles was considered. In Part III, presented here, their stability and efficacy are considered; Part IV will address their application in cosmetics.

Delivering Actives via Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Part II, Nanoparticle Characterization

Part I of this review on Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs) as delivery systems for cosmetic actives appeared in the October 2010 issue of Cosmetics & Toiletries magazine. Part II, presented here, describes how to characterize SLNs and NLCs; part III, in March 2012, will discuss the stability and occlusion properties of actives and liquids in SLNs and NLCs, and examine their efficacy. Finally, part IV, in May 2012, will discuss the use of SLNs and NLCs in cosmetic products.

Formulating for Delivery From Elastomeric Nonwoven Substrates

When developing moisturizers intended for application via nonwoven substrates, formulators must consider the hydrophobic oils, the affinity of those oils to the substrate, the add-on to the substrate and the stability of the compositions on the substrate. With these considerations, moisturizing formulations were developed and coated onto laminated substrates whose moisturization efficacies were evaluated as described here.

Nanoemulsions vs. Emulsions in the Delivery of Coenzyme Q10 and Tocopheryl Acetate

This article compares the ability of mixed emulsifier nanoemulsions and polysorbate 60 emulsions to deliver coenzyme Q10 and tocopheryl acetate into the skin. In vitro skin penetration data shows that in newborn pig skin, nanoemulsions can deliver higher amounts of both actives than emulsions.

Dispelling the 'Law of Wiechers' and Maximizing Actives Delivery

Jonathan Hadgraft, PhD, named "The Law of Wiechers in Cosmetics" after his friend and colleague. This law argues that all actives should be formulated at 3% for maximum delivery, which Wiechers recently discussed in honor of Hadgrafts's 60th birthday.

Delivering Actives via Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Part I

This first of a two-part series on SLNs and NLCs describes the differences between the two types and their delivery capabilities. The terms solid lipid nanoparticles and nanostructured lipid carriers are not very useful to distinguish these two delivery systems since both are solid, both are lipids, both are nanoparticles, and both are carrier systems. The only real difference between the two is the purity of the single lipid used in SLNs or multiple lipids used, i.e. one solid and one liquid, in NLCs. This factor has an enormous impact on the crystallinity of the lipid phase, which subsequently influences the loading capacity of the system for encapsulated active ingredients or API.

Environmentally Responsive Nanoparticles for Delivery as Assessed via Light Scattering and Near-infrared Imaging

Lipid-based nanoparticles were developed to respond to environmental stimuli and used as site-directed delivery systems. Through Dynamic Light Scattering (DLS), the self-assembly of these 10–40 nm particles was observed. In addition, the penetration of the particles through the stratum corneum was monitored in vivo using a novel Near-infrared Chemical Imaging (NIR-CI) technique.

Controlled-release Mechanisms of Fragrances

Fragrances are volatile and susceptible to oxidation, and can escape from a finished product over time. This limited longevity has led to the development of encapsulation and controlled-release techniques. The present article reviews methods for controlling the release of fragrance in personal care products, and describes their mechanisms of action.

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