Recent in Delivery (page 3 of 6)

Clinical Relevance of Topical Active Delivery Systems in Cosmetics

Depending on a drug or cosmetic ingredient’s intended target, topical delivery systems are broadly categorized as either transdermal drug or dermal drug/cosmetic. Transdermal drug delivery (TDD) is the controlled release of drugs through intact skin to obtain therapeutic levels systematically and to affect specified targets for specific purposes such as contraception, among others.

Nanotechnology and Skin Delivery: Infinitely Small or Infinite Possibilities?

Nanoparticles have been defined as single particles with a diameter less than 100 nm,4 which includes titanium dioxide in transparent, inorganic sun care products, and is usually extended to 200 nm to include the zinc oxide in those products. But nanoparticles are only a subset of nanomaterials, which can also include cyclodextrins and liposomes.

Nanoemulsions vs. Emulsions in the Delivery of Coenzyme Q10 and Tocopheryl Acetate

This article compares the ability of mixed emulsifier nanoemulsions and polysorbate 60 emulsions to deliver coenzyme Q10 and tocopheryl acetate into the skin. In vitro skin penetration data shows that in newborn pig skin, nanoemulsions can deliver higher amounts of both actives than emulsions.

Delivering Actives via Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Part I

This first of a four-part series on SLNs and NLCs describes the differences between the two types and their delivery capabilities. The terms solid lipid nanoparticles and nanostructured lipid carriers are not very useful to distinguish these two delivery systems since both are solid, both are lipids, both are nanoparticles, and both are carrier systems. The only real difference between the two is the purity of the single lipid used in SLNs or multiple lipids used, i.e. one solid and one liquid, in NLCs. This factor has an enormous impact on the crystallinity of the lipid phase, which subsequently influences the loading capacity of the system for encapsulated active ingredients or API.

Environmentally Responsive Nanoparticles for Delivery as Assessed via Light Scattering and Near-infrared Imaging

Lipid-based nanoparticles were developed to respond to environmental stimuli and used as site-directed delivery systems. Through Dynamic Light Scattering (DLS), the self-assembly of these 10–40 nm particles was observed. In addition, the penetration of the particles through the stratum corneum was monitored in vivo using a novel Near-infrared Chemical Imaging (NIR-CI) technique.

Controlled-release Mechanisms of Fragrances

Fragrances are volatile and susceptible to oxidation, and can escape from a finished product over time. This limited longevity has led to the development of encapsulation and controlled-release techniques. The present article reviews methods for controlling the release of fragrance in personal care products, and describes their mechanisms of action.

Dendrimersomes for Ingredient Delivery

According to Virgil Percec, PhD, a professor at the University of Pennsylvania, dendrimers are the answer to the stable, effective delivery of drugs and cosmetic actives to the skin. Percec’s team has researched the fundamentals of dendrimers for years but more recently published work on using dendrimers to deliver drugs, cosmetic ingredients and other materials to the skin.

Delivering Actives via Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Part II, Nanoparticle Characterization

The characterization of SLN or NLC nano-sized particles is considered. There are, in principle, four different types of chemicals in an SLN or NLC that have different influences: an active ingredient, which can degrade; lipids that influence particle size, crystallization and morphology; surfactants that influence agglomeration; and finally, water.

It's a Small World

This issue of Cosmetics & Toiletries magazine also looks within the nano-sized world to examine the benefits that tiny technologies can impart in personal care. Delivery is one benefit. While debate surrounds the depth to which they penetrate skin, nanomaterials are nonetheless believed by most experts to do so, to some degree.

Chitin Nanofibrils for Cosmetic Delivery

In the present article, the author explores the delivery capabilities of nanocrystal chitin nanofibrils. By establishing an ionic bond with water and forming complexes with various actives, this material can impart local or global activity and reach different levels of skin permeability to achieve variable cosmetic efficacy.

Taking Action

There sure is a lot of activity around actives—from regulatory scrutiny over functional product claims, to ingredient research, development, optimization and efficacy testing.

How the ‘Stuff’ in Formulations Impacts the Delivery of Actives

Formulations contain many ingredients that are vital for some important function, such as providing stability. However, what does this “stuff” do in terms of helping or (usually) hindering the delivery of the all-important active? And how much of the active is actually available to deliver? A few simple questions and measurements, described here, can provide a wealth of insight.

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