Recent in Delivery (page 2 of 5)

Swellable, Nanoporous Organosilica for Extended and Triggered Release

Nanoporous organosilica particles were developed to swell upon the addition of organic solvents. These are evaluated here for encapsulating and controlling the release of fragrance. Slower, continuous release was observed, suggesting their ability to extend sensory benefits. In addition, the stimulated release of encapsulated lidocaine was studied, and results implicate their use to deliver cosmetic actives.

Swellable, Nanoporous Organosilica for Extended and Triggered Release

Nanoporous organosilica particles were developed to swell upon the addition of organic solvents. These are evaluated here for encapsulating and controlling the release of fragrance. Slower, continuous release was observed, suggesting their ability to extend sensory benefits. In addition, the stimulated release of encapsulated lidocaine was studied, and results implicate their use to deliver cosmetic actives.

Saccharide Isomerate to Deeply Hydrate Skin and Scalp

Saccharide isomerate, designed to closely resemble a carbohydrate complex found in human stratum corneum, is shown here to provide up to 72 hr of deep hydration to skin and, for the first time, rinse-off soothing to the scalp. Its unique binding mechanism to skin and scalp create new opportunities for leave-on and rinse-off products.

Delivering On Time, In Full and On Target: Part II

This second installment continues a discussion from Cosmetics & Toiletries magazine’s May 2008 issue and is also based on a chapter written for the book Skin Barrier: Chemistry of Skin Delivery Systems. Practical information for the cosmetic formulator regarding optimization of skin delivery has been added.

Triggering Controlled Release of Fragrance

This column examines some of the recent patent literature on triggers for controlled release of fragrance and was, itself, triggered by a reading of Andreas Herrmann’s recent review of pro-fragrances in Angewandte Chemie.

Formulation Fantasies: A Discussion

Numerous claims made in the popular press misrepresent the facts about formulations, and cosmetic science is not well-served by this. Here, the authors examine a number of such statements. The influence of skin creams and formulations on the penetration of actives must be communicated in a responsible manner to the public if the industry is to banish prevalent myths.

Smart Materials for Triggered Release of Cosmetics

Smart polymers can be engineered to contain reactive molecules, commonly dubbed “molecular switches,” that respond to external stimuli and cause systemic changes to the polymer structure. The specificity of a molecular switch to a single stimulus is critical for controlled release, although multi-triggered systems capable of responding to systematic stimuli are being developed for advanced applications. Herein the authors describe several stimuli-responsive materials that have potential applications for personal care and related biomedical fields.

Protection of Retinol in Organosilica Microparticles

In this article, retinol encapsulated in organosilica microparticles (12–14% w/w) having an average particle size of 0.3 micron are shown in a 40-day test period to exhibit enhanced stability to oxidation when compared with similar commercial stabilized retinol products.

Formulating for Delivery From Elastomeric Nonwoven Substrates

When developing moisturizers intended for application via nonwoven substrates, formulators must consider the hydrophobic oils, the affinity of those oils to the substrate, the add-on to the substrate and the stability of the compositions on the substrate. With these considerations, moisturizing formulations were developed and coated onto laminated substrates whose moisturization efficacies were evaluated as described here.

Formulation Fantasies: A Discussion

Numerous claims made in the popular press misrepresent the facts about formulations, and cosmetic science is not well-served by this. Here, the authors examine a number of such statements. The influence of skin creams and formulations on the penetration of actives must be communicated in a responsible manner to the public if the industry is to banish prevalent myths.

Smart Materials for Triggerred Release of Cosmetics

Smart polymers can be engineered to contain reactive molecules, commonly dubbed “molecular switches,” that respond to external stimuli and cause systemic changes to the polymer structure. The specificity of a molecular switch to a single stimulus is critical for controlled release, although multi-triggered systems capable of responding to systematic stimuli are being developed for advanced applications. Herein the authors describe several stimuli-responsive materials that have potential applications for personal care and related biomedical fields.

Clinical Relevance of Topical Active Delivery Systems in Cosmetics

Depending on a drug or cosmetic ingredient’s intended target, topical delivery systems are broadly categorized as either transdermal drug or dermal drug/cosmetic. Transdermal drug delivery (TDD) is the controlled release of drugs through intact skin to obtain therapeutic levels systematically and to affect specified targets for specific purposes such as contraception, among others.

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