Nanotechnology and Skin Delivery: Infinitely Small or Infinite Possibilities?

By: Johann W. Wiechers, PhD, JW Solutions

Posted: December 19, 2008, from the January 2009 issue of Cosmetics & Toiletries.

page 13 of 13

Reproduction of all or part of this article is strictly prohibited.

References
Send e-mail to johann.wiechers@versatel.nl.
1. The Royal Society and The Royal Academy of Engineering, Nanoscience and nanotechnologies: Opportunities and uncertainties, The Royal Society and The Royal Academy of Engineering, London, UK, 2004, available at: www.nanotec.org.uk/report/summary.pdf (Accessed on Sep 21, 2008)
2. JW Wiechers, Skin delivery: What it is and why we need it, In Science and Applications of Skin Delivery Systems, JW Wiechers, ed, Carol Stream, IL, USA: Allured Publishing (2008) Chapter 1, pp 1-21
3. JW Wiechers, Nanotechnology and skin delivery: The skin delivery system, Excerpted from the current article and posted separately at www.cosmeticsandtoiletries.com/formulating/ingredient/delivery/35819194.html (Dec 9, 2008)
4. AD Maynard, Nanotechnology: The next big thing, or much ado about nothing? Ann Occup Hyg 51 1-12 (2007)
5. G Miller, Nanomaterials, sunscreens and cosmetics: small ingredients, big risks, Friends of the Earth Australia Nanotechnology project, with contributions from L Archer, E Pica, D Bell, R Senjen and G Kimbrell (May 2006) Accessible via nano.foe.org.au/filestore2/download/125/FoEA%20nano%20cosmetics%20report%20web.pdf (Accessed on Sep 4, 2008)
6. TE Bell, Understanding risk assessment of nanotechnology, available at www.nano.gov/Understanding_Risk_Assessment.pdf (Accessed on Sep 19, 2008)7. PJA Borm, D Robbins, S Haubold, T Kuhlbush, H Fissan, K Donaldson, R Schins, V Stone,
W Kreyling, J Lademann, J Krutmann, D Warheit and E Oberdorster, The potential risks of nanomaterials: A review carried out for ECETOC, Particle and Fibre Toxicology, 3 (2006) 11, Available as www.pubmedcentral.nih.gov/picrender.fcgi?artid=1584248&blobtype=pdf
8. AD Bangham, MM Standish and JC Watkins, Diffusion of univalent ions across the lamellae of swollen phospholipids, J Mol Biol 12 238-252 (1965)
9. JW Wiechers and AC Watkinson, The influence of formulation type on skin delivery, In Science and Applications of Skin Delivery Systems, JW Wiechers, ed, Carol Stream, IL, USA: Allured Publishing (2008) Chapter 5, pp 61-89
10. MS Roberts, The latest science (including safety) on nanotechnology and skin penetration, www.fda.gov/ohrms/dockets/dockets/06n0107/06n-0107-ts00014-Roberts.ppt (Accessed on Sep 17, 2008)
11. BM Magnusson, YG Anissimov, SE Cross and MS Roberts, Molecular size as the main determinant of solute maximum flux across the skin, J Invest Dermatol 122 993-999 (2004)
12. G Lian, L Chen and L Han, An evaluation of mathematical models for predicting skin permeability, J Pharm Sci 97 584-598 (2008)
13. A Rolland, N Wagner, A Chatelus, B Shroot and H Schaefer, Site-specific drug delivery to pilosebaceous structures using polymeric microspheres, Pharm Res 10 1738-1744 (1993)
14. M Ossadnik, H Richter, A Teichmann, S Koch, U Schäfer, R Wepf, W Sterry and J Lademann, Investigation of differences in follicular penetration of particle- and nonparticle-containing emulsions by laser scanning microscopy, Laser Physics 16 747-750 (2006)
15. J Lademann, H Richter, UF Schaefer, U Blume-Peytavi, A Teichmann, N Otberg and W Sterry, Hair follicles--A long-term reservoir for drug delivery, Skin Pharmacol Physiol 19 232-236 (2006)
16. R Toll, U Jacobi, H Richter, J Lademann, U Schaefer and U Blume-Peytavi, Penetration profile of microspheres in follicular targeting of terminal hair follicles, J Invest Dermatol 123 168-176 (2004)
17. J Lademann, H Richter, A Teichmann,
N Otberg, U Blume-Peytavi, J Luengo, B Weiss, UF Schaefer, C-M Lehr, R Wepf and W Sterry, Nanoparticles—An efficient carrier for drug delivery into hair follicles, Eur J Pharm Biopharm 66 159–164 (2007)
18. J Lademann, F Knorr, H Richter, U Blume-Peytavi, A Vogt, C Antoniou, W Sterry and A Patzelt, Hair follicles--An efficient storage and penetration pathway for topically applied substances, Skin Pharmacol Physiol 21 150-155 (2008)
19. N Otberg, H Richter, A Knuttel, H Schaefer,
W Sterry and J Lademann, Laser spectroscopic methods for the characterization of open and closed follicles, Laser Phys Letters 1 46-49 (2004)
20. A Teichmann, N Otberg, U Jacobi, W Sterry and J Lademann, Follicular penetration: Development of a method to block the follicles selectively against the penetration of topically applied substances, Skin Pharmacol Physiol 19 216–223 (2006)
21. GJ Nohynek, J Lademann, C Ribaud and MS Roberts, Grey goo on the skin? Nanotechnology, cosmetic and sunscreen safety, Crit Rev Toxicol 37 251–277 (2007)
22. F Pirot, J Millet, YN Kalia and P Humbert, In vitro study of percutaneous absorption, cutaneous bioavailability and bioequivalence of zinc and copper from five topical formulations, Skin Pharmacol 9 259–269 (1996)
23. SCCNFP, Opinion of the Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers Concerning Zinc Oxide COLIPA No. S 76. 24–25 June, 2003, Brussels, Belgium: European Commission, Available at: ec.europa.eu/food/fs/sc/sccp/out222_en.pdf
24. SE Cross, B Innes, MS Roberts, T Tsuzuki, TA Robertson and P McCormick, Human skin penetration of sunscreen nanoparticles: In vitro assessment of a novel micronized zinc oxide formulation, Skin Pharmacol Physiol 20 148–154 (2007)
25. A Gamer, E Leibold and B van Ravenzwaay, The in vitro absorption of microfine ZnO and TiO2 through porcine skin, Toxicol In Vitro 20 301–307 (2006)
26. JP, Ryman-Rasmussen, JE Riviere and
NA Monteiro-Riviere, Penetration of intact skin by quantum dots with diverse physicochemical properties, Toxicol Sci 91 159-165 (2006)
27. LW Zhang and NA Monteiro-Riviere, Assessment of quantum dot penetration into intact, tape-stripped, abraded and flexed rat skin, Skin Pharmacol Physiol 21 166-180 (2008)
28. JW Wiechers, Supplementary discussions of quantum dots and liposomes, excerpted from the current article and posted separately at www.cosmeticsandtoiletries.com/formulating/ingredient/delivery/35814559.html and
www.cosmeticsandtoiletries.com/formulating/ingredient/delivery/35814984.html (Dec 9, 2008)
29. J Hewitt, Inorganic sunscreens, In The Chemistry and Manufacture of Cosmetics,
ML Schlossman, ed, vol III, 3rd edn, Carol Stream, Illinois USA: Allured Publishing (2002) Book 1, Chapter 32, pp 527-551
30. U Jacobi, M Kaiser, R Toll, S Mangelsdorf,
H Audring, N Otberg, W Sterry and J Lademann, Porcine ear skin: an in vitro model for human skin, Skin Res Technol 13 19-24 (2007)
31. N Otberg, H Richter, H Schaefer, U Blume-Peytavi, W Sterry and J Lademann, Variations of hair follicle size and distribution in different body sites, J Invest Dermatol 122 14-19 (2004)
32. GJ Nohynek, EK Dufour and MS Roberts, Nanotechnology, cosmetics and the skin: Is there a health risk? Skin Pharmacol Physiol 21 136-149 (2008)
33. EB Souto and RH Müller, Challenging cosmetics—Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), In Science and Applications of Skin Delivery Systems, JW Wiechers, ed, Carol Stream, IL, USA: Allured Publishing (2008) Chapter 13, pp 227-250
34. EB Souto and RH Müller, Cosmetic features and applications of lipid nanoparticles (SLN, NLC), Int J Cosmet Sci 30 157-165 (2008)
35. RH Müller and A Dingler, The next generation after the liposomes: solid lipid nanoparticles (SLN, Lipopearls) as dermal carrier in cosmetics, Eurocosmetics 8(7) 18-26 (1998)
36. G Blume, Flexible liposomes for topical applications in cosmetics, In Science and Applications of Skin Delivery Systems, JW Wiechers, ed, Carol Stream, IL, USA: Allured Publishing (2008) Chapter 15, pp 269-282
37. PL Honeywell-Nguyen, GS Gooris and
JA Bouwstra, Quantitative assessment of the transport of elastic and rigid vesicle components and a model drug from these vesicle formulations into human skin in vivo, J Invest Dermatol 123 902-910 (2004)
38. PL Honeywell-Nguyen and JA Bouwstra, Vesicles as skin delivery vehicles, In Science and Applications of Skin Delivery Systems, JW Wiechers, ed, Carol Stream, IL, USA: Allured Publishing (2008) Chapter 12, pp 205-226
39. Y Frum, MC Bonner, GM Eccleston and VM Meidan, The influence of drug partition co-efficient on follicular penetration: In vitro human skin studies, Rur J Pharm Sci 30 280-287 (2007)