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Delivery
Delivering Actives via Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Part I
By: Johann W. Wiechers, PhD, JW Solutions, and Eliana B. Souto
Posted: September 29, 2010, from the October 2010 issue of Cosmetics & Toiletries.
Figures
- Figure 1. Schematic representation of SLNs (left) and NLCs (right); modified from Reference 4.
- Figure 2. The production process of lipid nanoparticles using cold (left, light gray) and hot (right, dark gray) high pressure homogenization; reproduced with permission from Reference 4.
- Figure 3. Models of actives incorporated in lipid nanoparticles, homogeneous matrix; a) type I SLNs, b) type II SLNs, and c) type III SLNs; modified from Reference 4.
- Figure 4. The effect of adding chemically different lipids to a pure lipid; at left, the melting and crystallization temperatures of a pure lipid are shown—both quite high and with a relatively small difference (i.e., supercooling).
- Figure 5. Summary of selection criteria of lipid materials to be used in SLNs and NLCs
page 9 of 9
References
Send e-mail to johann.wiechers@jwsolutions.com.
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2. JW Wiechers, Delivery Review—Looking at Liposomes, Cosm & Toil 120 (6) 77–86 (2005)
3. S Doktorovova and EB Souto, Nanostructured lipid carrier-based hydrogel formulations for drug delivery: A comprehensive review, Expert Opin Drug Del 6 165–176 (2009)
4. J Pardeike, A Hommoss and RH Müller, Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products, Int J Pharm 366 170–184 (2009)
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6. K Westesen, H Bunjes and MHJ Koch, Physicochemical characterization of lipid nanoparticles and evaluation of their drug loading capacity and sustained release potential, J Control Rel 48 223–236 (1997)
7. W Mehnert and K Mäder, Solid lipid nanoparticles. Production, application and applications, Adv Drug Del Rev 47 165–196 (2001) 8. EB Souto, AJ Almeida and RH Müller, Lipid nanoparticles (SLN, NLC) for cutaneous drug delivery: Structure, protection and skin effects, J Biomed Nanotechnol 3 317–331 (2007)
9. AJ Almeida and EB Souto, Solid lipid nanoparticles as a drug delivery system for peptides and proteins, Adv Drug Del Rev 59 478–490 (2007)
10. S Martins, B Sarmento, DC Ferreira and EB Souto, Lipid-based colloidal carriers for peptide and protein delivery—liposomes versus lipid nanoparticles, Int J Nanomed 2 595–607 (2007)
11. J Pardeike, K Schwabe and RH Müller, Influence of nanostructured lipid carriers (NLC) on the physical properties of the Cutanova Nanorepair Q10 cream and the in vivo skin hydration effect, Int J Pharm 396 166–173 (2010)
12. JW Wiechers, CL Kelly, TG Blease and JC Dederen, Formulating for Efficacy, Int J Cosmet Sci 26 173–182 (2004)
13. P Ahlin, J Kristl and J Šmid-Kobar, Optimization of procedure parameters and physical stability of solid lipid nanoparticles in dispersions, Acta Pharm 48 259–267 (1998)
14. V Jenning and S Gohla, Comparison of wax and glyceride solid lipid nanoparticles (SLN), Int J Pharm 196 219–222 (2000)
15. V Teeranachaideekul, EB Souto, RH Müller and VB Junyaprasert, Physicochemical characterization and in vitro release studies of ascorbyl palmitate-loaded semisolid nanostructured lipid carriers (NLC gels), J Microencaps 25 111–120 (2008)
