Antibacterial and Anti-inflammatory Effects of a Magnolia Extract

Jan 1, 2009 | Contact Author | By: Jongsung Lee, Eunsun Jung, Sungran Hur and Deokhoon Park, Biospectrum Life Science Institute; Anthony Ansaldi and Roy Heckl, DKSH North America Inc.
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Title: Antibacterial and Anti-inflammatory Effects of a Magnolia Extract
Magnoliax antibacterialx P. acnesx anti-inflammatoryx antimicrobialx irritationx acnex
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Keywords: Magnolia | antibacterial | P. acnes | anti-inflammatory | antimicrobial | irritation | acne

Abstract: P. acnes can exacerbate acne as a result of the inflammatory properties of the cell wall short chain fatty acids and chemotactic factors. Here, researchers investigate the effectiveness of a magnolia extract as an acne treatment, based on the known anti-inflammatory and antimicrobial effects from magnolol and honokiol within the material.

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Acne, an inflammatory disease of the sebaceous glands, is a common skin disease that induces inflammation at the skin surface of the face, neck, chest or back. Adolescents and young adults are most often afflicted, with estimates of 85–100% of 12- to 24-year-olds being affected, at least intermittently, during those years.1

The likelihood of developing acne is greatest during adolescence because hormone levels become elevated. Elevated hormones stimulate the sebaceous glands, which are attached to hair follicles, to produce greater amounts of sebum. An acne lesion such as a whitehead, blackhead or pimple occurs when a hair follicle becomes plugged with the sebum and dead cells. The etiology of acne lies in a confluence of several factors, including: hormonal imbalance, bacterial infection, stress, diet and the application of cosmetic products.

Propionibacterium acnes (P. acnes), one of the major organisms isolated from the skin’s surface,2specifically induces an inflammation in the sebaceous glands or hair pores.3 P. acnes secretes lipase and degrades sebum oils into free fatty acids (FFA), which are potent acne stimuli. FFA are major irritative components of skin surface lipids. Intracutaneous injection of small amounts of FFA, as compared with other surface lipids, produces a marked inflammatory response.4

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Lee footnotes

 a HerbEx Magnolia Extract (INCI: Water (Aqua) (and) Butylene Glycol (and) Magnolia Biondii  (Bark) Extract) is a product of Bio-Spectrum Inc.

b TIB 202 is a human monocytic THP-1 cell line produced by ATCC.

c RPMI 1640 was developed by Moore et al. at the Roswell Park Memorial Institute and is a product of Thermo Fisher Scientific.

d Dulbecco’s Modified Eagles Medium is a product of Thermo Fisher Scientific

e ATCC 6919 (P. Acnes) and ATCC 25564 

(P. granulosum) are produced by ATCC.

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