A Medicinal Plant Blend for Soothing and Anti-inflammatory Effects

Apr 1, 2009 | Contact Author | By: Jongsung Lee, Eunsun Jung, Kwangseon Jung and Deokhoon Park, Biospectrum Life Science Institute; and Anthony Ansaldi and Roy Heckl, DKSH North America Inc.
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Title: A Medicinal Plant Blend for Soothing and Anti-inflammatory Effects
atopic dermatitisx anti-inflammatory effectx pro-inflammatory cytokinesx EASIx
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Keywords: atopic dermatitis | anti-inflammatory effect | pro-inflammatory cytokines | EASI

Abstract: The use of steroids to treat atopic dermatitis (AD) often causes side effects; thus, the authors present a blend of plant-derived materials designed as an alternative treatment or an adjuvant therapeutic agent. Through in vitro and in vivo evaluations, the blend is shown to provide effective anti-inflammatory and AD-mitigating effects.

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Atopic dermatitis (AD) is a chronic inflammatory skin disease that most commonly occurs during early infancy and childhood and is characterized by a chronically relapsing course where symptoms of AD are ameliorated and aggravated repeatedly. Although the pathogenesis of AD is not fully understood, it has been reported that it is associated with multiple immunologic abnormalities.1,2 The most prominent findings of immune dysfunction are the high level of immunoglobulin E (IgE) in peripheral blood and increased IgE production by B cells. In AD, T helper 2 (Th2) cells are mainly activated and then secrete interleukin-4 (IL-4), interleukin-5 (IL-5) and interleukin-10 (IL-10).1, 3, 4

Symptoms of AD induced by signal transduction pathways of IgE, IL-4, IL-5 or IL-10 are associated with inflamed skin damage as well as skin dryness. Accordingly, the generally accepted prescription includes moisturizers and topical steroids that maintain a level of moisture in the skin and suppress inflammatory reaction, respectively. However, treating AD over time with topical steroid hormones has been known to induce adverse side effects.5 In addition, nonsteroid therapeutic treatments including cyclosporin A and tacrolimus have been reported to induce cutaneous T cell lymphoma, fever, extreme rises in serum alkaline phosphatase in children, enhanced irritation and relapsing Kaposi’s varicelliform eruption.6–10 Therefore, much recent work has focused on the development of therapeutic agents that maximize anti-inflammatory effects while minimizing side effects.

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Table 1. Compounds formulated in the test blend

 Table 1. Compounds formulated in the test blend


Figure 1. The test blend inhibited LPS

 Figure 1. The test blend inhibited LPS

Figure 2. LPS-induced IL-8

 Figure 2. LPS-induced IL-8 

Figure 3. LPS-induced TNF

 Figure 3. LPS-induced TNF

Figure 4. The test blend inhibited PHA

 Figure 4. The test blend inhibited PHA

Figure 5. Cytotoxity of the test blend

 Figure 5. Cytotoxity of the test blend

Lee A Medicinal Plant Blend footnotes

 a MultiEx BSASM (INCI: Chamomilia Recutita (Matricaria) Flower Extract (and) Centella Asiatica Extract (and) Glycyrrhiza Glabra (Licorice) Root Extract (and) Camellia Sinensis Leaf Extract (and) Polygonum Cuspidatum Root Extract (and) Rosmarinus Officinalis (Rosemary) Leaf Extract (and) Scutellaria Baicalensis Root Extract (and) Butylene Glycol (and) Water (aqua)) is a product of BioSpectrum Inc., distributed by DKSH North America Inc.

b Lipopolysaccharide is a product of Sigma-Aldrich.
c Phytohematoaglutinin is a product of EMD Chemicals/Calbiochem.
d IL-8 ELISA kit is a product of R&D System.
e TNF-a Human ELISA kit is a product of Invitrogen.
f NF-κB DNA is a product of Stratagene.
g RPMI-1640 is a product of Sigma-Aldrich.
h Thymidine kinase promoter is a product of Promega.
j The Dual-Glo Luciferase Assay System used for this study is a product of Promega.
k The LB953 luminometer is a product of Berthold.
m SuperFect Transfection Reagent is a product of Qiagen.
n Power Wave is a product of Bio-tek Inc.

Formula 1. Test blend

 Formula 1. Test blenda

Formula 2. Face/body wash

 Formula 2. Face/body wash


Formula 3. Liposome lotion

 Formula 3. Liposome lotion

Formula 4. Liposome serum

 Formula 4. Liposome serum


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