Mouse Study Identifies Target for Itch and Eczema Treatment

Jun 22, 2015

According to Rachel Brem, geneticist and associate professor at the Buck Institute for Research on Aging, in Novato, California, an estimated 10% to 20% of the population will suffer from chronic itch at some point in their life.

Oak, Green Tea and Orange Derivatives to Disrupt JAK/STAT, NF-κB Irritation Pathways

Jan 1, 2011Giorgio Dell’Acqua, PhD; Kuno Schweikert, PhD; and Giuseppe Calloni, Induchem AG

Activation of NF-κB and JAK/STAT pathways in keratinocytes leads to the release of immunomodulating factors that sustain an amplification loop between the keratinocyte and infiltrating immune cell, leading to skin irritation. To disrupt this loop, two complexes, one based on oak and green tea extracts, and another on orange flavonoids, were developed and are shown here to immediately soothe skin.

Reducing Skin Stress Response with Willow Bark-derived Salicin

Jul 1, 2010Remona Gopaul and Helen Knaggs, PhD, Nu Skin Global Research and Development; Anna Langerveld, PhD, Genemarkers LLC

Heat shock proteins (HSPs) are stress-induced and initiate a cascade of protective mechanisms when the skin is exposed to stressful conditions. In the present research, salicin extracted from white willow bark was found to influence the activity of HSPs through HSP70 and other key regulators.

Raspberry Stem Cell Extract to Protect Skin from Inflammation and Oxidative Stress

Jul 1, 2010Ani Barbulova, Annalisa Tito, Antonietta Carola, Marida Bimonte, Francesco De Laurentis, Pasquale D’Ambrosio, Fabio Apone and Gabriella Colucci, Arterra Bioscience; Irene Monoli and Mirna Cucchiara, INTERCOS SpA; Jacqueline Hill, CRB SA

In the present article, the authors evaluate a wild red raspberry (Rubus idaeus) extract for its beneficial compounds and potential applications in skin care. From leaf explants, raspberry stem cells were obtained to develop an extract rich in antioxidants, anthocyanins and phenolics. This extract exhibited anti-inflammatory and antioxidant activities.

An Herbal Blend for Antiaging Effects: TCM in Personal Care

Jan 1, 2009Daniel Schmid, Esther Belser and Fred Zülli, Mibelle Biochemistry

A combination of Chinese herbs is shown here, by gene array analysis, to stimulate the skin’s resistance against free radicals, oxidative stress and toxic molecules, while also reducing extracellular matrix degradation. The extract also is shown to help against skin irritation in vivo.