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Patent Picks—Methyl Naphthalenyl Ketone, Oxylipins, Metal Oxide Shell Microcapsules, Tsuga, Furanone and More for the Treatment of Skin Inflammation and Irritation
By: Katie Anderson (Schaefer), Cosmetics & Toiletries magazine
Posted: July 26, 2011
page 4 of 6
Disclosed are novel oxylipins, referred to herein as docosanoids, that are derived from C22 polyunsaturated fatty acids, and method of making and using such oxylipins. Also disclosed is the use of docosapentaenoic acid (C22:5n-6) (DPAn-6), docosapentaenoic acid (C22:5n-3) (DPAn-3), and docosatetraenoic acid (DTAn-6: C22:4n-6) as substrates for the production of novel oxylipins, and to the oxylipins produced thereby. Also disclosed is the use of DPAn-6, DPAn-3, DTAn-6, and/or the oxylipins derived therefrom, and/or novel docosanoids derived from the structures of C22 fatty acids, in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. The invention also relates to novel ways of producing long chain polyunsaturated acid (LCPUFA)-rich oils and compositions that contain enhanced and effective amounts of LCPUFA-derived oxylipins, and particularly, docosanoids.
Microcapsules Comprising Active Ingredients and Metal Oxide Shell, A Method for Their Preparation and Uses Thereof
US Patent Application 20110177951
Publication Date: July 21, 2011
Assignee: Sol-Gel Technologies Ltd.
The present invention relates to a process for preparing microcapsules comprising a core material encapsulated by a metal oxide shell, said process comprising: (a) preparing an o/w emulsion by emulsification of an oily phase that comprises a core material, in an aqueous phase, wherein one or both of the oily phase, and the aqueous phase comprises a sol-gel precursor; (b) including metal oxide nanoparticles in said aqueous phase either prior, during or after (a); and (c) applying conditions to obtain microcapsules.
The invention further relates to microcapsules obtainable by the process as described in the present invention. The invention additionally relates to microcapsules comprising a core material encapsulated by a metal oxide shell, wherein said core material is (i) a liquid or (ii) a dispersion in liquid; wherein the thickness of said shell is in the range 0.1-10 micron; and wherein said shell is obtained from (a) metal oxide nanoparticles, and (b) a hydrolyzed and polymerized sol gel precursor. Moreover, the invention relates to a composition comprising microcapsules as described in the present invention; and a carrier. The invention additionally relates to a method for treating a surface condition in a subject, comprising topically administering onto the surface a composition as described in the invention, wherein the core material comprises a topically acting active agent.
The invention further relates to a composition comprising microcapsules as described in the present invention, wherein the core material comprises a topically acting active agent, for treatment of a disease or disorder selected from acne, infection, inflammation, puritis, psoriasis, seborrhea, contact dermatitis, rosasea, and a combination thereof. Moreover, the invention relates to use of microcapsules as described in the present invention, wherein the core material comprises a topically acting active agent for the preparation of a medicament for topical administration on the skin or mucosal membrane. Additionally, the invention relates to compositions for pest control comprising microcapsules as described in the present invention, wherein said core material comprises a pesticide.