Treating Wrinkles with Dimethylaminoethanol, Retinol and Mineral Salts

Apr 1, 2008 | Contact Author | By: C. Bertin, C. Robert, M. Jousselin and N. Issachar, Johnson & Johnson; E. Camel, Institut d’Expertise Clinique
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Title: Treating Wrinkles with Dimethylaminoethanol, Retinol and Mineral Salts
dimethylaminoethanolx retinolx mineral saltsx wrinklesx agingx
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Keywords: dimethylaminoethanol | retinol | mineral salts | wrinkles | aging

Abstract: A placebo-controlled study was conducted to determine if the appearance of wrinkles on facial skin could be improved by a combination of three cosmetic ingredients: dimethylaminoethanol, retinol and mineral salts. Both clinical assessment and video analysis of cutaneous replicas showed a significant improvement of the wrinkle appearance.

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Age-related changes in skin appearance including dryness, wrinkling and laxity, are influenced by the behavior of keratinocytes and fibroblasts. As individuals age, skin cells replace themselves more slowly and the lower layer of the skin, the dermis, decreases in thickness. The network of elastin and collagen fibers that allows human skin to stretch and retract begins to unravel.

On the face, thinner and less elastic skin tends to sag and fold. Permanent crease lines and crow’s-feet form on the brow and around the eyes. Tiny wrinkles form around the lips. The tissues of the jaw and neck droop into jowls and double chins. Skin aging is affected by genetic factors such as skin color, environmental factors such as prolonged exposure to the sun,4,5 and the consequences of a lifestyle involving smoking, rapid weight loss and stress.6,7 The aging process cannot be stopped or reversed but good daily skin care can slow the process.

This article describes a placebo-controlled study conducted to determine if the combination of dimethylamino-ethanol, retinol and mineral salts has a positive effect on one aspect of skin aging, the appearance of wrinkles in facial skin.

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Table 1. Percentage change in clinical

 Table 1. Percentage change in clinical

Table 2. Percentage change in SIA crow's foot

 Table 2. Percentage change in SIA

Table 3. Percentage change in SIA eyebrows

 Table 3. Percentage change in SIA eyebrows

Figure 1. Example of results

 Figure 1. Example of results 

DMAE’s Mechanism of Action

 DMAE’s Mechanism of Action

Bertin Treating Wrinkles footnotes

 a Silflo silicone rubber is a product of Flexico Corp.

b Skin Image Analyser (SIA) is a device from Monaderm, Monaco.
c Quantirides is a program from Monaderm, Monaco.

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