Cellulite: Evolving Technologies to Fight the 'Orange Peel' Battle

Sep 1, 2009 | Contact Author | By: Karl Lintner, PhD, Sederma SAS
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Title: Cellulite: Evolving Technologies to Fight the 'Orange Peel' Battle
cellulitex hypertrophyx lipogenesisx drainagex Bupleurum falcatum root extractx
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Keywords: cellulite | hypertrophy | lipogenesis | drainage | Bupleurum falcatum root extract

Abstract: This article focuses on the structure of cellulite and examines materials that claim to affect its appearance via mechanisms such as lipolysis, lipogenesis, water drainage, tissue repair and the firming of skin.

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Editor’s note: Some technologies to treat cellulite, such as those described here, impart physical effects but for cosmetic benefits. Product developers are reminded that the US Food and Drug Administration reviews claims made on labels to determine whether products require drug registration and testing. While the treatments named here may blur the line between cosmetics and drugs, topical formulas that provide visible results are in high demand and a formulating reality.

According to some dermatologists, 85% of women in Western regions have cellulite—and the remaining 15% who do not have it think they do. The cosmetics industry in Europe and North America, much less so in Asia, has increased efforts to research this phenomenon and to market products that help alleviate the symptoms. As the underlying causes and structures are understood in more detail, product developers are better armed to develop topical treatments to reduce the appearance of cellulite, or what is often called orange peel skin (see Figure 1).

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Figure 1. Typical appearance of cellulite in skin

 Figure 1. Typical appearance of cellulite in skin

Figure 2. The consequences of hypertrophied adipocyte tissue

 Figure 2. The consequences of hypertrophied adipocyte tissue 

Figure 3. Ultrasound image of dermis with cellulite protrusion clearly visible

 Figure 3. Ultrasound image of dermis with cellulite protrusion clearly visible 

Figure 4. Simplified schematic of selected biochemical reactions

 Figure 4. Simplified schematic of selected biochemical reactions

Figure 5. Decrease of fat layer thickness

 Figure 5. Decrease of fat layer thickness 

Figure 6. Visible results of improvement of the cellulite aspect

 Figure 6. Visible results of improvement of the cellulite aspect 

Figure 7. Mean thickness (mm) of cellulitic infiltration

 Figure 7. Mean thickness (mm) of cellulitic infiltration

Lintner Cellulite footnotes

 aPleuriminicyl (INCI: Butylene glycol (and) PEG-8 (and) Bupleurum falcatum root extract (and) caffeine (and) water (aqua)) is a product of Sederma SAS.

Formula 1: Anticellulite cream tested in vivo

 Formula 1: Anticellulite cream tested in vivo

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