Narcissus Tazetta and Schizandra Chinensis to Regulate ‘Youth Gene Clusters’—An In vitro Analysis

Jun 1, 2012 | Contact Author | By: R. Gopaul; D.G. Kern; H.E. Knaggs, PhD; and J.F. Lephart; Nu Skin Enterprise, Provo, Utah USA
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Title: Narcissus Tazetta and Schizandra Chinensis to Regulate ‘Youth Gene Clusters’—An In vitro Analysis
anti-agingx youth gene clusterx elastinx collagenx moisturizationx proliferationx
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Keywords: anti-aging | youth gene cluster | elastin | collagen | moisturization | proliferation

Abstract: A blend of Narcissus tazetta bulb and Schizandra chinensis fruit extracts was developed for anti-aging benefits and tested for efficacy on a human skin equivalent. Results indicate it regulates the functions of youth gene clusters by increasing the activities found in younger skin and reducing the activities found in aging skin specific to structure, hydration, cellular proliferation and pigmentation.

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R Gopaul, DG Kern, HE Knaggs and JF Lephart, Narcissus tazetta and Schizandra chinensis to regulate ‘youth gene clusters’—An in vitro analysis, Cosm & Toil 127(6) 446-450 (Jun 2012)

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Skin aging is a multifactorial process regulated by various biological mechanisms. It is often accompanied by the appearance of skin dryness, wrinkles, sagging, uneven skin tone, mottled pigmentation, etc.; and research has shown that each of the biological mechanisms responsible for a particular skin aging attribute is regulated by genes. Thousands of genes are expressed in the epidermis and their collective expression is known as the gene expression profile. Groups of genes coding for proteins having similar or complementary functions may be responsible for regulating specific skin aging attributes. These genes may be categorized into groups of “functional clusters”; herein, gene clusters associated with anti-aging activities are referred to as youth gene clusters.

Recent research also has shown that topical as well as nutritional materials may influence the gene expression profile of the skin to reflect a more youthful profile. The present article describes in vitro analyses of a blend of two extracts, namely Narcissus tazetta bulb and Schizandra chinensis fruit, for such effects. Narcissus tazetta bulb extract, a bulb extract from the daffodil plant family, has previously been shown to delay cellular proliferation when applied topically. In addition, Schizandra chinensis fruit extract, a red berry fruit extract belonging to the magnolia plant family, has been used for decades in Chinese medicine to promote general well-being and vitality when taken orally. This has led to the hypothesis that when combined, the two extracts may change the activity of genes in the epidermis to reflect a more youthful gene expression profile, which is assessed here. Note that the individual actives were not tested; future research is necessary to determine whether they have similar effects alone.

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This content is adapted from an article in GCI Magazine. The original version can be found here.

 

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Table 1. qPCR dataset for skin structure and integrity

Table 1. qPCR dataset for skin structure and integrity

Examples of qPCR dataset of upregulation of genes associated with various biological processes contributing to skin structure and integrity

Table 2. qPCR dataset for skin hydration and barrier protection

Table 2. qPCR dataset for skin hydration and barrier protection

Examples of qPCR dataset of regulation of genes associated with various biological processes contributing to skin hydration and barrier protection

Table 3. qPCR dataset contributing to cellular differentiation

Table 3. qPCR dataset contributing to cellular differentiation

Examples of qPCR dataset of regulation of genes associated with various biological processes contributing to cellular differentiation

Table 4. qPCR dataset for UV-induced skin pigmentation and protection

Table 4. qPCR dataset for UV-induced skin pigmentation and protection

Examples of qPCR dataset of regulation of genes associated with various biological processes contributing to UV-induced skin pigmentation and protection

Footnotes [Gopaul 127(6)]

a The full-thickness epidermal equivalents (FTEE) used for this study are manufactured by MatTek, Ashland, MA.

b, c The validated gene expression assays and High Capacity cDNA Reverse Transcription Kit used for this study are manufactured by Life Technologies, Foster City, CA, USA.

d, e The 7900HT device and RQ Manager software is manufactured by Applied Biosystems, Foster City, CA USA.

f StatMiner (v3.1) software programs are manufactured by Integromics S.L., Granada, Spain.

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