Slowing Intrinsic and Extrinsic Aging: A Dual Approach

May 1, 2009 | Contact Author | By: Liki von Oppen-Bezalel, IBR Ltd.
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Title: Slowing Intrinsic and Extrinsic Aging: A Dual Approach
antiagingx photoagingx intrinsic agingx extrinsic agingx cell proliferationx oxidationx dorminsx colorless carotenoidsx
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Keywords: antiaging | photoaging | intrinsic aging | extrinsic aging | cell proliferation | oxidation | dormins | colorless carotenoids

Abstract: In this dual approach to antiaging, intrinsic factors are first addressed by slowing cell proliferation in skin via a technology based on dormins—in this case, extracts from dormant Narcissus tazetta bulb. Then, to protect against extrinsic aging, colorless carotenoids are employed to absorb UV radiation and prevent oxidative stress damage.

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When designing products for maximum antiaging benefits, formulators should consider both intrinsic and extrinsic aging factors—intrinsic being naturally programmed aging, and extrinsic resulting from accumulated damage. This article describes a combined approach to reduce the signs of aging, the first of which focuses on intrinsic aging by slowing cell proliferation rate to preserve cells in their younger stage. The second approach aims at extrinsic factors to protect the skin from photo- and oxi- dative damage.

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Table 1. SPF of sunscreen creams with and without P&P

 Table 1. SPF of sunscreen creams with and without P&P

 

Figure 1. Effects of dormant and nondormant bulb extract

 Figure 1. Effects of dormant and nondormant bulb extract

Figure 2. Sensory analysis of dormins in a cosmetic cream

 Figure 2. Sensory analysis of dormins in a cosmetic cream

Figure 3. The colorless carotenoids phytoene and phytofluene absorption spectra

 Figure 3. The colorless carotenoids phytoene and phytofluene absorption spectra

von Oppen a dual approach footnotes

 a IBR-Dormin (INCI: Water (aqua) (and) Narcissus Tazetta Bulb Extract) is a product and registered trademark of IBR Ltd. 

b IBR Colorless Carotenoids (IBR CLC and TCLC) (INCI: Dunaliella Salina Extract; and INCI: Solanum Lycopersicum (Tomato) Fruit Extract, respectively) are products and registered trademarks of IBR Ltd. 

Formula 1. Antiaging and moisturizing o/w day cream

 Formula 1. Antiaging and moisturizing o/w day cream

 

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