Treating Wrinkles with Dimethylaminoethanol, Retinol and Mineral Salts

By: C. Bertin, C. Robert, M. Jousselin and N. Issachar, Johnson & Johnson; E. Camel, Institut d’Expertise Clinique

Posted: March 28, 2008, from the April 2008 issue of Cosmetics & Toiletries.

Age-related changes in skin appearance including dryness, wrinkling and laxity, are influenced by the behavior of keratinocytes and fibroblasts. As individuals age, skin cells replace themselves more slowly and the lower layer of the skin, the dermis, decreases in thickness. The network of elastin and collagen fibers that allows human skin to stretch and retract begins to unravel.

On the face, thinner and less elastic skin tends to sag and fold. Permanent crease lines and crow’s-feet form on the brow and around the eyes. Tiny wrinkles form around the lips. The tissues of the jaw and neck droop into jowls and double chins. Skin aging is affected by genetic factors such as skin color, environmental factors such as prolonged exposure to the sun,4,5 and the consequences of a lifestyle involving smoking, rapid weight loss and stress.6,7 The aging process cannot be stopped or reversed but good daily skin care can slow the process.

This article describes a placebo-controlled study conducted to determine if the combination of dimethylamino-ethanol, retinol and mineral salts has a positive effect on one aspect of skin aging, the appearance of wrinkles in facial skin.

This is only an excerpt of the full article that appeared in Cosmetics & Toiletries, but you can purchase the full-text version.