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Silab has sourced soy to create an active that fights the signs of aging by boosting collagen I synthesis. Pro-Coll-One+ (INCI: Hydrolyzed Soy Fiber) is based on highly purified hydroxyproline-rich glycoproteins, the glycopeptides found in soy. The company compared 0.25% of the soy active with palmitoyl pentapeptide-3 and found the soy active stimulates collagen I synthesis in normal human fibroblasts by 1,190%—results similar to those produced by palmitoyl pentapeptide-3.
In addition, the company tested the anti-wrinkle effect of the active by comparing it at 2% to 3% palmitoyl pentapeptide-3 and 0.075% retinol. Each of the three actives was applied to healthy female volunteers twice daily for 56 days and compared to a placebo. Crow’s-feet improved in 78% of the volunteers with application of the soy active, and the volunteers found the active comparable to palmitoyl pentapeptide-3 and retinol.