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New in Antiaging (page 2 of 11)
Sep 04, 2012 | 11:10 AM CDT
By: Cecilia Teran, Durant Scholz, Julie Cava, Kath…
Whether formulating for Asia, North America, Europe or Latin America, the cosmetic chemist will face one common demand in all these markets: an even skin tone. This article provides an overview of chemical and biological agents capable of causing hypopigmentation via interactions through different stages of the melanogenic pathway.
Jul 03, 2012 | 02:46 PM CDT
From Elastin to Elastic Fibers, Part I: The In vitro Effects of a Natural Dipeptide on the Biological Cascade
By: Philippe Mondon and Ada Andre - Sederma, Franc…
The peptide N-Acetyl-Tyr-Arg-Hexadecylester (NATAH) was found to stimulate the synthesis of tropoelastin in cultured human dermal fibroblasts as well as augment the activity of all important actors in the assembly of elastic fibers, including Fibrillin 1, Fibulin 5, Decorin, LOX and Transglutaminase, among others. This is shown here both in monolayer cell cultures and in a 3D skin model.
Jun 04, 2012 | 03:24 PM CDT
By: R. Gopaul; D.G. Kern; H.E. Knaggs, PhD; and J.…
A blend of Narcissus tazetta bulb and Schizandra chinensis fruit extracts was developed for anti-aging benefits and tested for efficacy on a human skin equivalent. Results indicate it regulates the functions of youth gene clusters by increasing the activities found in younger skin and reducing the activities found in aging skin specific to structure, hydration, cellular proliferation and pigmentation.
Mar 30, 2012 | 03:14 PM CDT
By: Estelle Loing, PhD, Unipex Innovations, Québec…
Recent work indicates that the biomarker progerin, in conjunction with dysfunctioning telomeres, triggers cellular senescence. In response, trifluoroacetyl-tripeptide-2, a synthetic tripeptide, was developed to decrease progerin production, thereby regulating biological mechanisms involved in the aging process and reducing the cosmetic effects of aging, which are explored here.
Mar 30, 2012 | 02:49 PM CDT
By: Arthur Georgalas
The skin care industry strives to formulate products based on nature’s remedies. However, formulators of such products seek more scientific guidance to determine whether a particular natural material measures up to its synthetic counterpart.
Nov 04, 2011 | 01:17 PM CDT
By: Jean-Francois Nicolay and Christophe Paillet, …
Cell membrane-derived lipidic hydroperoxides, introduced into the skin by environmental stresses, seem to be key players in oxidative stress-mediated extrinsic aging. Imidazole-containing peptidomimetics can protect against their toxicity through a variety of mechanisms.
Sep 01, 2011 | 01:50 PM CDT
By: Giorgio Dell’Acqua, PhD, and Christian Wagner,…
Skin discoloration and excessive pigmentation due to increased melanin production is associated with skin inflammation and aging. Therefore, an extract rich in acetylated hydroxystilbenes from Rheum rhaponticum was combined with panthenyl triacetate to test in the melanogenesis pathway. The complex strongly reduced melanogenesis and melanin accumulation in human skin explants, decreased melanin content in pigmented spots, increased skin brightness and enhanced skin radiance on the face of human volunteers in a double-blind clinical study.
Sep 01, 2011 | 01:45 PM CDT
By: Marida Bimonte, Antonietta Carola, Annalisa Ti…
Coffea species have been widely evaluated for effects including oxidative stress protection and immunomodulation. The present study therefore evaluates the cosmetic activity of an extract obtained from cultured Coffea bengalensis stem cells. Results showed the extract imparted hydration activity in the keratinocytes, stimulated collagen synthesis in the fibroblasts and enhanced adipocyte differentiation starting from mesenchymal precursor cells.
Sep 01, 2011 | 01:39 PM CDT
By: Craig Bonda, Jean Zhang and Anna Pavlovic, The…
In this study, the effects of ultraviolet radiation (UVR) on trans-resveratrol were documented, finding that UV radiation causes it to undergo rapid and extensive photoisomerization and some photodecomposition. The antioxidant activity of trans-resveratrol is correspondingly reduced. However, in the presence of ethylhexyl methoxycrylene, a photostabilizer used in sunscreens, the effects of UV exposure on trans-resveratrol are minimized, thereby preserving its antioxidant activity and, presumably, its bioavailability.
Sep 01, 2011 | 01:34 PM CDT
By: Michael J. Fevola, PhD, Johnson & Johnson
L-Ascorbic acid (AscA), more commonly referred to as vitamin C, is best known for its vital role in human health and nutrition, where it functions as a cofactor in enzymatic reactions, such as collagen synthesis, and as an antioxidant.