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New in Antiaging (page 2 of 11)
Jan 04, 2013 | 12:43 PM CST
By: Rosanna Mootoo, Stephanie Basile, Cristina St…
There are varying definitions, associations and overall impressions of fine lines and wrinkles among different consumer segments. The findings of this study offer invaluable insight into consumers’ opinions, and by qualitative in-depth interviews, they provide a well-defined vernacular for aging descriptors. This language is critical for developmental research, consumer evaluation and marketing within the cosmetic industry.
Dec 04, 2012 | 11:40 AM CST
By: L. Bergeron; K. Cucumel, PhD; Y. Guerif; L. Mu…
Oxidative stress is a major factor in skin aging, thus a topical compound was designed to increase anti-oxidant coenzyme Q10 (CoQ10) within the body. Described here are in vivo and in vitro studies assessing the compound’s antioxidant and anti-aging capabilities. Results indicate that the modulation of intracellular CoQ10 and its binding proteins appears to protect skin from oxidative damage.
Oct 01, 2012 | 02:29 PM CDT
By: Virginie Nollent, PharmD; Marion Lanctin; Ale…
A zinc and copper complex generating biomimetic electricity on a physiological level is shown here to improve the signs of photoaging in preclinical and clinical studies. This complex was applied to the eye area to confirm its efficacy as an anti-aging treatment option with good skin tolerance.
Sep 04, 2012 | 11:36 AM CDT
From Elastin to Elastic Fibers, Part II: The Clinical Effects of a Natural Dipeptide on the Biological Cascade
By: Philippe Mondon, Sebastian Fache and Emmanuel …
The peptide N-Acetyl-Tyr-Arg-Hexadecylester (NATAH), found in Part I to stimulate the production of elastic fibers in vitro, was next tested in vivo for its capacity to improve skin elasticity parameters, using various biophysical and imaging techniques. Significant differences in facial ptosis and extensibility were observed in the 56-day, vehicle-controlled clinical study described here.
Sep 04, 2012 | 11:10 AM CDT
By: Cecilia Teran, Durant Scholz, Julie Cava, Kath…
Whether formulating for Asia, North America, Europe or Latin America, the cosmetic chemist will face one common demand in all these markets: an even skin tone. This article provides an overview of chemical and biological agents capable of causing hypopigmentation via interactions through different stages of the melanogenic pathway.
Jul 03, 2012 | 02:46 PM CDT
From Elastin to Elastic Fibers, Part I: The In vitro Effects of a Natural Dipeptide on the Biological Cascade
By: Philippe Mondon and Ada Andre - Sederma, Franc…
The peptide N-Acetyl-Tyr-Arg-Hexadecylester (NATAH) was found to stimulate the synthesis of tropoelastin in cultured human dermal fibroblasts as well as augment the activity of all important actors in the assembly of elastic fibers, including Fibrillin 1, Fibulin 5, Decorin, LOX and Transglutaminase, among others. This is shown here both in monolayer cell cultures and in a 3D skin model.
Jun 04, 2012 | 03:24 PM CDT
By: R. Gopaul; D.G. Kern; H.E. Knaggs, PhD; and J.…
A blend of Narcissus tazetta bulb and Schizandra chinensis fruit extracts was developed for anti-aging benefits and tested for efficacy on a human skin equivalent. Results indicate it regulates the functions of youth gene clusters by increasing the activities found in younger skin and reducing the activities found in aging skin specific to structure, hydration, cellular proliferation and pigmentation.
Mar 30, 2012 | 03:14 PM CDT
By: Estelle Loing, PhD, Unipex Innovations, Québec…
Recent work indicates that the biomarker progerin, in conjunction with dysfunctioning telomeres, triggers cellular senescence. In response, trifluoroacetyl-tripeptide-2, a synthetic tripeptide, was developed to decrease progerin production, thereby regulating biological mechanisms involved in the aging process and reducing the cosmetic effects of aging, which are explored here.
Mar 30, 2012 | 02:49 PM CDT
By: Arthur Georgalas
The skin care industry strives to formulate products based on nature’s remedies. However, formulators of such products seek more scientific guidance to determine whether a particular natural material measures up to its synthetic counterpart.
Nov 04, 2011 | 01:17 PM CDT
By: Jean-Francois Nicolay and Christophe Paillet, …
Cell membrane-derived lipidic hydroperoxides, introduced into the skin by environmental stresses, seem to be key players in oxidative stress-mediated extrinsic aging. Imidazole-containing peptidomimetics can protect against their toxicity through a variety of mechanisms.