Skin Lightening Gel
Posted: September 8, 2006
Company: Pentapharm Inc. (Centerchem Inc.)
| A. | |
| Water (aqua) | 77.30 |
| Hydroxyethylcellulose (Natrosol 250 HHR, Hercules F) | 1.50 |
| PEG/PPG-20/6 dimethicone (Abil B 88183, Degussa/Goldschmidt) | 2.00 |
| B. | |
| Glycerin | 3.00 |
| Preservative | qs |
| C. | |
| Sodium hydroxide, 10% | qs to pH 8.5 |
| Citric Acid | qs to pH 4.0-5.0 |
| D. | |
| Ethoxydiglycol (EDG Plus ,Moelhausen S.p.A.) | 5.00 |
| E. | |
| Water (aqua) | 10.00 |
| Alpha-Arbutin (Alpha-Arbutin, Pentapharm) | 1.00 |
| Benzophenone-9 (Uvinul DS 49, BASF) | 0.20 |
Procedure: For A, disperse hydroxyethylcellulose in water, then add PEG/PPG-20/6 dimethicone. Mix B, then add it to A. Adjust the pH to approx. 8.5 with NaOH 10% (of C) to obtain a clear gel. Then adjust the pH to approx. 4.0-5.0 with citric acid (also of C). Add D under stirring. Add E and mix to obtain a homogeneous gel.