Figure 1. The mechanism of Nrf2

Nrf2 is in the cytoplasm of cells and attached to the protein Keap 1. When oxidative stress reaches the cell, Nrf2 is released from Keap 1 and translocates to the cell nucleus. In the nucleus, Nrf2 binds to another protein, electrophile-response element (ARE), in the promoter region of the nucleus (shown as a dark rectangle). In this way, a variety of genes are activated through transcription. Source: