Figure 1. Molecular pathway for the modulation of lipolysis by ZAG in adipocytes

ZAG has recently emerged as an adipokine involved in lipid mobilization. It directly modulates lipid metabolism via β-3- and β-2(or β-1)-adrenergic receptors in rodents and humans, respectively, leading to activation of a cAMP-dependant pathway. Increasing the level of cAMP activates hormone sensitive lipase (HSL) that catalyzes the hydrolysis of triglycerides into fatty acids and glycerol.