Figure 6. The occlusion factor of lipid nanoparticles

The occlusion factor of lipid nanoparticles; with identical lipid content, reducing the particle size leads to an increase in particle number, and a) the film becomes denser, increasing the occlusion factor. At a given particle size, increasing the lipid concentration increases the number of particles, density of the film, and therefore b) the occlusivity factor. By varying the size and lipid concentration, the occlusion can be fine tuned. The film becomes denser due to the creation of multiple layers of nanoparticles, c) if the lipid content is kept constant; source, a) and b), Reference 1.