Figure 4. Cyproterone acetate penetration into human skin in vitro

Cyproterone acetate penetration into human skin in vitro; dispersions of drug loaded carrier systems (0.05%) were applied to cryo-conserved human skin for 6 hr. Particulate dispersions were tested in parallel to, and delivery expressed relative to, an o/w cream. NE = nano-emulsion; SLN = solid lipid nanoparticle; NLC-O = nanostructured lipid carrier + oleic acid; NLC-M = nanostructured lipid carrier + caprylic/capric triglycerides; MS = microspheres; * = a statistically significant difference in delivery over the cream (p < 0.05); reproduced with permission from Reference 13.