Figure 4. Treatment with 0.4% PN complex inhibited chemokine synthesis in human keratinocytes induced with a cytokine mixture; * = statistically significant.

As shown in Table 1 and Figures 2, 3 and 4, treatment of NHEK with the Oncostatin M + IL-17 + TNF-a cytokine mix dramatically increased the transcription of JAK/ STAT signaling markers, cytokines and chemokines mRNA; by 681%, 3,744% and 10,761%, respectively.